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KMID : 0352819880040010079
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Kosin Medical Journal
1988 Volume.4 No. 1 p.79 ~ p.84
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Mitomycin C-induced Polymorphism in C-band Regions of Human 1,9,16 and Y
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Abstract
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Mitomycin C is known to induce somatic crossing over in lower eukaryotes. This study is carried out to find out that Mitomycin C might also induce mitotic crossing over in human lymphocytes. Peripheral blood lymphocyte from normal males were treated with mitomycin C. Mitomycin C was able to alter C-band polymorphism of human chromosomes 1, 9, 16. Evidence is presented which show that mitomycin C-induced C-band polymorphism arise from mitotic crossing over.
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